The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection

Author:

La Bella Alyssa Ann1ORCID,Andersen Marissa Jeme1ORCID,Gervais Nicholas C.2ORCID,Molina Jonathan Jesus1ORCID,Molesan Alex1ORCID,Stuckey Peter V.1ORCID,Wensing Lauren2ORCID,Nobile Clarissa J.34ORCID,Shapiro Rebecca S.2ORCID,Santiago-Tirado Felipe Hiram1ORCID,Flores-Mireles Ana Lidia1ORCID

Affiliation:

1. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.

2. Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.

3. Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, USA.

4. Health Sciences Research Institute, University of California, Merced, Merced, CA, USA.

Abstract

Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections (HAIs). As 20 to 50% of hospitalized patients receive catheters, CAUTIs are one of the most common HAIs, resulting in increased morbidity, mortality, and health care costs. Candida albicans is the second most common CAUTI uropathogen, yet relative to its bacterial counterparts, little is known about how fungal CAUTIs are established. Here, we show that the catheterized bladder environment induces Efg1- and fibrinogen (Fg)–dependent biofilm formation that results in CAUTI. In addition, we identify the adhesin Als1 as the critical fungal factor for C. albicans Fg-urine biofilm formation. Furthermore, we show that in the catheterized bladder, a dynamic and open system, both filamentation and attachment are required, but each by themselves are not sufficient for infection. Our study unveils the mechanisms required for fungal CAUTI establishment, which may aid in the development of future therapies to prevent these infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Candida albicans Biofilms and Human Disease

2. Pathogenesis ofCandida albicansbiofilm

3. World Health Organization WHO fungal priority pathogens list to guide research development and public health action (World Health Organization 2022).

4. F. L. Mayer, D. Wilson, B. Hube, Candida albicans pathogenicity mechanisms, Virulence 4, 119–128 (2013).

5. Coevolution of Morphology and Virulence in Candida Species

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3