The local microenvironment limits the regenerative potential of the mouse neonatal heart

Author:

Notari Mario1ORCID,Ventura-Rubio Antoni1ORCID,Bedford-Guaus Sylvia J.12ORCID,Jorba Ignasi345ORCID,Mulero Lola1,Navajas Daniel345ORCID,Martí Mercè12ORCID,Raya Ángel126ORCID

Affiliation:

1. Center of Regenerative Medicine in Barcelona (CMRB), Hospital Duran i Reynals, 3rd Floor, Av. Gran Via 199-203, 08098 Hospitalet de Llobregat, Barcelona, Spain.

2. Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

3. Institute for Bioengineering of Catalonia, 08028 Barcelona, Spain.

4. School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.

5. Center for Networked Biomedical Research on Respiratory Diseases (CIBERES), Madrid, Spain.

6. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.

Abstract

Decreasing ECM stiffness rescues the regeneration ability of the neonatal mouse heart.

Funder

Fundació la Marató de TV3

Generalitat de Catalunya

Departament d’Innovació, Universitats i Empresa, Generalitat de Catalunya

Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

Departament de Salut, Generalitat de Catalunya

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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