Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization-Reference-Cited by-同舟云学术

Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization

Published:2021-08-13 Issue:33 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bell Nicholas A. W.¹²^ORCID,Haynes Philip J.²³⁴^ORCID,Brunner Katharina¹⁵,de Oliveira Taiana Maia⁶,Flocco Maria M.⁶^ORCID,Hoogenboom Bart W.²⁴^ORCID,Molloy Justin E.¹^ORCID

Affiliation:

1. The Francis Crick Institute, London NW1 1AT, UK.

2. London Centre for Nanotechnology, University College London, London WC1H 0AH, UK.

3. Molecular Sciences Research Hub, Department of Chemistry, Imperial College London, London W12 0BZ, UK.

4. Department of Physics and Astronomy, University College London, London WC1E 6BT, UK.

5. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.

6. Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

Abstract

A combination of single-molecule methods shows that PARP1 condenses double-stranded DNA by a loop stabilization mechanism.

Funder

AstraZeneca

Wellcome

Medical Research Council

Engineering and Physical Sciences Research Council

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference73 articles.

1. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

2. A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

3. Transcriptional Roles of PARP1 in Cancer

4. Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

5. Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation

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