Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors-Reference-Cited by-同舟云学术

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Published:2018-08-03 Issue:8 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lee Sung-Bau¹²^ORCID,Segura-Bayona Sandra³^ORCID,Villamor-Payà Marina³,Saredi Giulia¹^ORCID,Todd Matthew A. M.¹⁴,Attolini Camille Stephan-Otto³^ORCID,Chang Ting-Yu²,Stracker Travis H.³^ORCID,Groth Anja¹⁴^ORCID

Affiliation:

1. Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

2. Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

3. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

4. Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

Abstract

TLKs promote nucleosome assembly and prevent fork collapse and DNA damage upon checkpoint or PARP inhibition.

Funder

Ministry of Science and Technology

European Research Council

Danish National Research Foundation

Ministerio de Economía y Competitividad

Taipei Medical University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. Causes and consequences of replication stress

2. PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

3. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation

4. Chromatin replication and epigenome maintenance

5. New histone supply regulates replication fork speed and PCNA unloading

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