Restriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase-Reference-Cited by-同舟云学术

Restriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase

Published:2019-02 Issue:2 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Hou Lidan¹²^ORCID,Zhao Jie³^ORCID,Gao Shaobing¹⁴^ORCID,Ji Tong³,Song Tianyu¹²^ORCID,Li Yining¹,Wang Jingjie¹,Geng Chenlu¹,Long Min¹,Chen Jiang³^ORCID,Lin Hui³,Cai Xiujun³,Cang Yong²^ORCID

Affiliation:

1. Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3. Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.

4. Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, China.

Abstract

c-Abl inhibits replication of hepatitis B virus by promoting CRL4 Cdt2 -mediated destruction of the viral polymerase.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

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2. Medical virology of hepatitis B: How it began and where we are now;Gerlich W. H.;Virol. J.,2013

3. Hepatitis B viruses: Reverse transcription a different way

4. Prevention of hepatitis B virus-associated liver diseases by antiviral therapy;Tawada A.;Hepatol. Int.,2016

5. Management of patients with hepatitis B who require immunosuppressive therapy;Hwang J. P.;Nat. Rev. Gastroenterol. Hepatol.,2014

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