RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity-Reference-Cited by-同舟云学术

RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity

Published:2021-03-05 Issue:10 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Wenwen¹²^ORCID,Jia Mutian¹²^ORCID,Zhao Chunyuan¹²³^ORCID,Yu Zhongxia¹²,Song Hui¹²,Qin Ying¹²,Zhao Wei¹²^ORCID

Affiliation:

1. Department of Immunology and Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong, China.

2. State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, China.

3. Department of Cell Biology, School of Basic Medical Science, Shandong University, Jinan, Shandong, China.

Abstract

An E3 ubiquitin ligase controls DDX3X ubiquitination and stability and therefore suppresses RLR-dependent antiviral responses.

Funder

Academy of Medical Sciences

National Natural Science Foundation of China

National Key Research and Developmental Program of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference37 articles.

1. Regulation of cGAS- and RLR-mediated immunity to nucleic acids

2. RIG-I-like receptors: their regulation and roles in RNA sensing

3. Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

4. Pattern Recognition Receptors and Inflammation

5. RIG-I and Other RNA Sensors in Antiviral Immunity

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