Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome-Reference-Cited by-同舟云学术

Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome

Published:2021-02-12 Issue:7 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

D’Acunzo Pasquale¹²^ORCID,Pérez-González Rocío¹²^ORCID,Kim Yohan¹²^ORCID,Hargash Tal¹^ORCID,Miller Chelsea¹,Alldred Melissa J.¹²^ORCID,Erdjument-Bromage Hediye³⁴^ORCID,Penikalapati Sai C.¹^ORCID,Pawlik Monika¹^ORCID,Saito Mitsuo²⁵,Saito Mariko²⁶^ORCID,Ginsberg Stephen D.¹²⁷⁸^ORCID,Neubert Thomas A.³⁴^ORCID,Goulbourne Chris N.¹,Levy Efrat¹²⁷⁹^ORCID

Affiliation:

1. Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

2. Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.

3. Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

4. Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

5. Division of Analytical Psychopharmacology, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

6. Division of Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

7. NYU Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

8. Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.

9. Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Newly identified mitovesicles are a type of extracellular vesicles whose levels and cargo are altered in Down syndrome.

Funder

National Institute on Drug Abuse

National Institute on Aging

NIH shared instrumentation grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

2. Reassessment of Exosome Composition

3. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

4. Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

5. Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

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