Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer

Author:

Huang San-Shan12ORCID,Lee Keng-Jung2ORCID,Chen Hung-Chih2ORCID,Prajnamitra Ray Putra2ORCID,Hsu Chia-Hsin2ORCID,Jian Cheng-Bang345ORCID,Yu Xu-En36,Chueh Di-Yen7,Kuo Chiung Wen7,Chiang Tsai-Chen8,Choong Oi Kuan2ORCID,Huang Shao-Chan2,Beh Chaw Yee2ORCID,Chen Li-Lun2ORCID,Lai James J.9ORCID,Chen Peilin7ORCID,Kamp Timothy J.10ORCID,Tien Yu-Wen8ORCID,Lee Hsien-Ming3ORCID,Hsieh Patrick Ching-Ho1291011ORCID

Affiliation:

1. Ph.D. Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.

2. Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

3. Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.

4. Department of Chemistry, National Taiwan University, Taipei 115, Taiwan.

5. Nano Science and Technology Program, Taiwan International Graduate Program, Academia Sinica and National Taiwan University, Taipei, Taiwan.

6. Department of Chemistry, National Central University, Chung-Li 32001, Taiwan.

7. Research Center for Applied Sciences, Academia Sinica, Taipei 115, Taiwan.

8. Department of Surgery, National Taiwan University and Hospital, Taipei 100, Taiwan.

9. Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

10. Department of Medicine and Stem Cell and Regenerative Medicine Center, University of Wisconsin, Madison, WI 53705, USA.

11. Institute of Medical Genomics and Proteomics and Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan.

Abstract

Aptamer-based nanovectors that actively bind to circulating monocytes enhance drug delivery to the heart and to cancer.

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

National Health Research Institutes

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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