MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection-Reference-Cited by-同舟云学术

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

Published:2019-01-04 Issue:1 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Arifuzzaman Mohammad¹^ORCID,Mobley Yuvon R.¹^ORCID,Choi Hae Woong²^ORCID,Bist Pradeep³,Salinas Cristina A.⁴,Brown Zachary D.⁵,Chen Swaine L.⁶⁷^ORCID,Staats Herman F.²⁸⁹^ORCID,Abraham Soman N.¹²³⁸^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

2. Department of Pathology, Duke University, Durham, NC 27710, USA.

3. Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

4. Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.

5. Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.

6. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

7. Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.

8. Department of Immunology, Duke University, Durham, NC 27710, USA.

9. Department of Medicine, Duke University, Durham, NC 27710, USA.

Abstract

Selective activation of local mast cells promotes healing of bacterial skin infections and protects against reinfection.

Funder

NIH Clinical Center

Duke-NUS Graduate Medical School, Singapore

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection

5. Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance;St. John A. L.;Proc. Natl. Acad. Sci. U.S.A.,2011

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