The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication

Author:

Jiang Min12ORCID,Xie Xie3ORCID,Zhu Xuefeng3ORCID,Jiang Shan4ORCID,Milenkovic Dusanka2ORCID,Misic Jelena4ORCID,Shi Yonghong3,Tandukar Nirwan5ORCID,Li Xinping6ORCID,Atanassov Ilian6ORCID,Jenninger Louise3,Hoberg Emily3,Albarran-Gutierrez Sara2ORCID,Szilagyi Zsolt3,Macao Bertil3,Siira Stefan J.78ORCID,Carelli Valerio910ORCID,Griffith Jack D.5,Gustafsson Claes M.3,Nicholls Thomas J.11ORCID,Filipovska Aleksandra78ORCID,Larsson Nils-Göran4ORCID,Falkenberg Maria3ORCID

Affiliation:

1. Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China.

2. Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

3. Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.

4. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.

5. Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27514, USA.

6. Proteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

7. Harry Perkins Institute of Medical Research and ARC Centre of Excellence in Synthetic Biology, Nedlands, WA 6009, Australia.

8. Telethon Kids Institute, Northern Entrance, Perth Children’s Hospital, 15 Hospital Avenue, Nedlands, WA, Australia.

9. Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

10. IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.

11. Wellcome Centre for Mitochondrial Research, Biosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Abstract

The mitochondrial single-stranded DNA binding protein is required for initiation of DNA synthesis in mammalian cells.

Funder

Wellcome

Swedish Cancer Foundation

European Research Council

Swedish Research Council Formas

H2020 European Research Council

National Health and Medical Research Council

Knut och Alice Wallenbergs Stiftelse

Västra Götalandsregionen

USA National Institutes of Environmental Health Sciences

Stockholms Läns Landsting

Wellcome Trust and the Royal Society

Rosetrees and Stoneygate Trust Research Fellowship

Swedish Research Council

the Australian Research Council

the Cancer Council of Western Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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