Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy-Reference-Cited by-同舟云学术

Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy

Published:2020-02-07 Issue:6 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xiao Zecong¹^ORCID,Su Zhenwei¹^ORCID,Han Shisong¹^ORCID,Huang Jinsheng¹^ORCID,Lin Liteng²^ORCID,Shuai Xintao¹^ORCID

Affiliation:

1. PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China.

2. Department of Minimally Invasive Interventional Radiology, and Laboratory of Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510275, China.

Abstract

A potent drug delivery strategy promotes tumor infiltration of T cells and unleashes antitumor immunity.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

The Natural Science Foundation of Guangdong Province

the Guangdong Innovative and Entrepreneurial Research Team Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. The blockade of immune checkpoints in cancer immunotherapy

2. The future of immune checkpoint therapy

3. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

4. Antigen-induced regulatory T cells in autoimmunity

5. Regulatory T cells, tumour immunity and immunotherapy

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