TRIM26 is a critical host factor for HCV replication and contributes to host tropism-Reference-Cited by-同舟云学术

TRIM26 is a critical host factor for HCV replication and contributes to host tropism

Published:2021-01-06 Issue:2 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Liang Yisha¹²³^ORCID,Zhang Guigen⁴⁵^ORCID,Li Qiheng⁴^ORCID,Han Lin¹²³,Hu Xiaoyou¹³,Guo Yu⁴^ORCID,Tao Wanyin¹^ORCID,Zhao Xiaomin⁶,Guo Mingzhe¹²³,Gan Tianyu¹³,Tong Yimin¹,Xu Yongfen¹,Zhou Zhuo⁴,Ding Qiang⁶,Wei Wensheng⁴^ORCID,Zhong Jin¹²³^ORCID

Affiliation:

1. Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3. University of Chinese Academy of Sciences, Beijing 100049, China.

4. Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.

5. Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510000, China.

6. Center for Infectious Diseases Research, School of Medicine, Tsinghua University, Beijing 100084, China.

Abstract

A genome-wide screening revealed that TRIM26 is a host factor for HCV replication and a new determinant for host tropism.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Beijing Municipal Science and Technology Commission

the West Light Foundation of the Chinese Academy of Sciences

the Beijing Advanced Innovation Center for Genomics at Peking University

the Peking-Tsinghua Center for Life Sciences

Publisher

American Association for the Advancement of Science (AAAS)