FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure-Reference-Cited by-同舟云学术

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Published:2021-07-16 Issue:29 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

González-Loyola Alejandra¹^ORCID,Bovay Esther¹^ORCID,Kim Jaeryung¹^ORCID,Lozano Tania Wyss¹²^ORCID,Sabine Amélie¹^ORCID,Renevey Francois³^ORCID,Arroz-Madeira Silvia¹^ORCID,Rapin Alexis⁴^ORCID,Wypych Tomasz P.⁵^ORCID,Rota Giorgia³,Durot Stephan⁶^ORCID,Velin Dominique⁷^ORCID,Marsland Benjamin⁵,Guarda Greta⁸,Delorenzi Mauro¹²^ORCID,Zamboni Nicola⁶^ORCID,Luther Sanjiv A.³^ORCID,Petrova Tatiana V.¹^ORCID

Affiliation:

1. Department of Oncology, University of Lausanne and Ludwig Institute for Cancer Research Lausanne, Epalinges 1066, Switzerland.

2. SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.

3. Department of Biochemistry, University of Lausanne, Epalinges 1066, Switzerland.

4. École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

5. Department of Immunology and Pathology, Monash University, Melbourne 3800, Australia.

6. Institute of Molecular Systems Biology ETH, Zurich 8093, Switzerland.

7. Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland.

8. Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.

Abstract

Foxc2 sustains adult lymphatic vascular specialization and coordinates organ-specific lymph flow, gut microbiota, and inflammation.

Funder

Seventh Framework Programme

Human Frontier Science Program

Swiss National Science Foundation

Université de Lausanne

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference80 articles.

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3. Development and aging of the lymphatic vascular system

4. Heterogeneity in the lymphatic vascular system and its origin

5. FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

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