The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli

Author:

Pedrotti Simona1ORCID,Caccia Roberta1,Neguembor Maria Victoria1ORCID,Garcia-Manteiga Jose Manuel2ORCID,Ferri Giulia1ORCID,de Palma Clara3ORCID,Canu Tamara4ORCID,Giovarelli Matteo5,Marra Paolo4ORCID,Fiocchi Amleto6,Molineris Ivan2ORCID,Raso Michele6,Sanvito Francesca7,Doglioni Claudio7ORCID,Esposito Antonio4,Clementi Emilio58,Gabellini Davide1ORCID

Affiliation:

1. IRCCS San Raffaele Scientific Institute, Division of Genetics and Cell Biology, Milano, Italy.

2. IRCCS San Raffaele Scientific Institute, Center for Translational Genomics and BioInformatics, Milano, Italy.

3. Unit of Clinical Pharmacology, University Hospital “L. Sacco”-ASST Fatebenefratelli Sacco, Milano, Italy.

4. IRCCS San Raffaele Scientific Institute, Preclinical Imaging Facility, Milano, Italy.

5. Department of Biomedical and Clinical Sciences “L. Sacco”, Università degli Studi di Milano, Milano, Italy.

6. IRCCS San Raffaele Scientific Institute, Mouse Clinic, Milano, Italy.

7. IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology, Milano, Italy.

8. Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.

Abstract

Suv420h proteins regulate PPAR-γ and the pathways controlling metabolism and weight balance in response to environmental stimuli.

Funder

FSHD Global Research Foundation

FSH Society

Italian Association for Cancer Research

Italian Ministry of Health

ERA-Net for Research on Rare Diseases

EPIGEN

Marie Curie Individual Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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