Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels

Author:

Kurth Isabel1ORCID,Yamaguchi Norihiro2ORCID,Andreu-Agullo Celia1ORCID,Tian Helen S.2ORCID,Sridhar Subhasree1,Takeda Shugaku1ORCID,Gonsalves Foster C.1,Loo Jia Min23ORCID,Barlas Afsar4,Manova-Todorova Katia4ORCID,Busby Robert1ORCID,Bendell Johanna C.5,Strauss James6ORCID,Fakih Marwan7ORCID,McRee Autumn J.8,Hendifar Andrew E.9,Rosen Lee S.10ORCID,Cercek Andrea4,Wasserman Robert1,Szarek Michael11112,Spector Scott L.1,Raza Syed1,Tavazoie Masoud F.1ORCID,Tavazoie Sohail F.2ORCID

Affiliation:

1. Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.

2. Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

3. Laboratory of Precision Oncology and Tumor Evolution, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.

4. Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA.

5. Sarah Cannon Research Institute, 250 25th Ave N, Nashville, TN 37203, USA.

6. Mary Crowley Cancer Research, Building C, 7777 Forest Ln #707, Dallas, TX 75230, USA.

7. City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010, USA.

8. The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA.

9. Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.

10. Jonsson Comprehensive Cancer Center, University of California, 10833 Le Conte Ave, Los Angeles, CA 90024, USA.

11. University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045, USA.

12. SUNY Downstate Health Sciences University School of Public Health, 450 Clarkson Ave, Brooklyn, NY 11203, USA.

Abstract

RGX-202, a small-molecule creatine transporter SLC6A8 inhibitor, suppresses colorectal cancer and modulates human creatine levels.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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