Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Published:2023-09-22 Issue:38 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Baldeon Vaca Gabriela¹^ORCID,Meyer Michelle²³^ORCID,Cadete Ana¹^ORCID,Hsiao Chiaowen Joyce¹^ORCID,Golding Anne¹,Jeon Albert¹,Jacquinet Eric¹,Azcue Emily¹^ORCID,Guan Chenxia Monica¹,Sanchez-Felix Xavier¹,Pietzsch Colette A.²³^ORCID,Mire Chad E.²³^ORCID,Hyde Matthew A.²³^ORCID,Comeaux Margaret E.²³^ORCID,Williams Julie M.²³,Sung Jean C.¹,Carfi Andrea¹,Edwards Darin K.¹,Bukreyev Alexander²³⁴^ORCID,Bahl Kapil¹^ORCID

Affiliation:

1. Moderna Inc., Cambridge, MA, USA.

2. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

3. Galveston National Laboratory, Galveston, TX, USA.

4. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Abstract

Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adh1655

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