FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Author:

Rota Ioanna A.1ORCID,Handel Adam E.12ORCID,Maio Stefano1ORCID,Klein Fabian1ORCID,Dhalla Fatima1ORCID,Deadman Mary E.1ORCID,Cheuk Stanley1ORCID,Newman Joseph A.3ORCID,Michaels Yale S.4ORCID,Zuklys Saulius5,Prevot Nicolas1ORCID,Hublitz Philip6ORCID,Charles Philip D.7ORCID,Gkazi Athina Soragia8ORCID,Adamopoulou Eleni1,Qasim Waseem8ORCID,Davies Edward Graham8,Hanson Imelda9ORCID,Pagnamenta Alistair T.1011ORCID,Camps Carme1011ORCID,Dreau Helene M.12ORCID,White Andrea13,James Kieran13ORCID,Fischer Roman7ORCID,Gileadi Opher3ORCID,Taylor Jenny C.1011ORCID,Fulga Tudor4ORCID,Lagerholm B. Christoffer14,Anderson Graham13,Sezgin Erdinc515ORCID,Holländer Georg A.1516ORCID

Affiliation:

1. Department of Paediatrics and the MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

2. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

3. Structural Genomics Consortium, University of Oxford, ORCRB, Roosevelt Drive, Oxford, UK.

4. Genome Engineering and Synthetic Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

5. Paediatric Immunology, Department of Biomedicine, University of Basel and University Children’s Hospital Basel, Basel, Switzerland.

6. MRC Weatherall Institute of Molecular Medicine, Genome engineering services, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

7. Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK.

8. Great Ormond Street Hospital and Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.

9. Department of Pediatrics, Section of Pediatric Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, TX, USA.

10. National Institute for Health Research Biomedical Research Centre, Oxford, UK.

11. Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

12. Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.

13. Institute for Immunology and Immunotherapy, Medical School, University of Birmingham, Birmingham B15 2TT, UK.

14. Wolfson Imaging Centre Oxford, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK.

15. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

16. Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Abstract

A dominant transcription factor mutation disrupting nuclear liquid phase separation causes human immunodeficiency.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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