Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection

Author:

Tan Lei1ORCID,Fu Jieni2ORCID,Feng Fan1ORCID,Liu Xiangmei1ORCID,Cui Zhenduo2ORCID,Li Bo3ORCID,Han Yong3ORCID,Zheng Yufeng4ORCID,Yeung Kelvin Wai Kwok5ORCID,Li Zhaoyang2ORCID,Zhu Shengli2ORCID,Liang Yanqin2ORCID,Feng Xiaobo6ORCID,Wang Xianbao1ORCID,Wu Shuilin2ORCID

Affiliation:

1. Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

2. School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

3. State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China.

4. State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

5. Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

6. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Abstract

Engineered probiotics biofilms prevent MRSA infection and improve bone integration through immunoregulation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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