The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author:

Hodgkinson Tom12ORCID,Tsimbouri P. Monica1,Llopis-Hernandez Virginia1ORCID,Campsie Paul3ORCID,Scurr David4ORCID,Childs Peter G.5ORCID,Phillips David6ORCID,Donnelly Sam1ORCID,Wells Julia A.7ORCID,O’Brien Fergal J.2ORCID,Salmeron-Sanchez Manuel5ORCID,Burgess Karl8,Alexander Morgan4ORCID,Vassalli Massimo5ORCID,Oreffo Richard O. C.7ORCID,Reid Stuart3ORCID,France David J.6ORCID,Dalby Matthew J.1ORCID

Affiliation:

1. Centre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

2. Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, Dublin D2, Ireland.

3. SUPA Department of Biomedical Engineering, University of Strathclyde, Glasgow G1 1QE, UK.

4. School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, UK.

5. Centre for the Cellular Microenvironment, Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, UK.

6. School of Chemistry, College of Science and Engineering, University of Glasgow, Glasgow G12 8QQ, UK.

7. Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.

8. Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of Glasgow, Switchback Rd., Bearsden, Glasgow G61 1BD, UK.

Abstract

Osteogenic activity metabolites can be identified in nanovibrational culture and have their specificity and potency enhanced.

Funder

Biotechnology and Biological Sciences Research Council

European Research Council

EPSRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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