PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability-Reference-Cited by-同舟云学术

PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability

Published:2021-05-07 Issue:19 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ma Shuai¹^ORCID,Cao Cheng¹^ORCID,Che Shiyou²^ORCID,Wang Yuejiao¹^ORCID,Su Dongxue³^ORCID,Liu Shuai¹^ORCID,Gong Wenchen¹,Liu Ling¹^ORCID,Sun Jixue²,Zhao Jiao¹^ORCID,Wang Qian¹^ORCID,Song Nan¹^ORCID,Ge Tong¹^ORCID,Guo Qiushi¹^ORCID,Tian Shanshan¹^ORCID,Chen Charlie Degui⁴,Zhang Tao¹^ORCID,Wang Ju¹,Ding Xiang⁵^ORCID,Yang Fuquan⁵^ORCID,Ying Guoguang¹,Yang Jie¹^ORCID,Zhang Kai¹^ORCID,Zhu Yi¹^ORCID,Yao Zhi¹^ORCID,Yang Na²^ORCID,Shi Lei¹^ORCID

Affiliation:

1. State Key Laboratory of Experimental Hematology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin...

2. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of Tianjin, Nankai University, 300353 Tianjin, China.

3. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

4. State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

5. Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

PHF8-promoted non-histone methylation switch plays a critical role in replication stress response and genome integrity.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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