Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

Author:

Meinhardt Marcus W.1ORCID,Pfarr Simone1,Fouquet Grégory2ORCID,Rohleder Cathrin3456ORCID,Meinhardt Manuela L.1,Barroso-Flores Janet1ORCID,Hoffmann Rebecca1,Jeanblanc Jérôme2ORCID,Paul Elisabeth1ORCID,Wagner Konstantin1ORCID,Hansson Anita C.1,Köhr Georg17ORCID,Meier Nils8,von Bohlen und Halbach Oliver8ORCID,Bell Richard L.9ORCID,Endepols Heike451011,Neumaier Bernd48ORCID,Schönig Kai12ORCID,Bartsch Dusan12ORCID,Naassila Mickaël2ORCID,Spanagel Rainer1ORCID,Sommer Wolfgang H.113ORCID

Affiliation:

1. Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.

2. Université de Picardie Jules Verne, INSERM UMRS, 1247 Amiens, France.

3. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

4. Institute of Radiochemistry and Experimental Molecular Imaging, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

5. Department of Multimodal Imaging, Max Planck Institute for Neurological Research, Cologne, Germany.

6. Brain and Mind Centre, The University of Sydney, Sydney, Australia.

7. Department of Neurophysiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

8. Institute for Anatomy and Cell Biology, Universitätsmedizin Greifswald, Greifswald, Germany.

9. Department of Psychiatry, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

10. Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

11. Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Jülich, Germany.

12. Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

13. Department of Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Abstract

Alcohol-induced mGluR2 deficits are restored by psilocybin, resulting in a rescue of pathological behaviors in alcoholism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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