Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design-Reference-Cited by-同舟云学术

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Published:2020-10-16 Issue:42 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rut Wioletta¹^ORCID,Lv Zongyang²³,Zmudzinski Mikolaj¹^ORCID,Patchett Stephanie⁴,Nayak Digant²³^ORCID,Snipas Scott J.⁵^ORCID,El Oualid Farid⁶^ORCID,Huang Tony T.⁴,Bekes Miklos⁷^ORCID,Drag Marcin¹⁵^ORCID,Olsen Shaun K.²³

Affiliation:

1. Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.

2. Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

3. Department of Biochemistry and Structural Biology University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

4. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

5. Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

6. UbiQ Bio B.V., 1098 XH, Amsterdam, Netherlands.

7. Independent Consultant.

Abstract

A multidisciplinary approach yields novel inhibitors and reveals substrate specificity, structure, and mechanisms of CoV-2 PLpro.

Funder

National Institutes of Health

Foundation For Polish Science

Narodowe Centrum Nauki

Hollings Cancer Center Postdoctoral Fellow

American Cancer Society Postdoctoral Fellow

Office of the Vice President for Research at the Medical University of South Carolina

Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility

NIH Shared Instrumentation Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003

2. SARS and MERS: recent insights into emerging coronaviruses

3. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

4. A novel coronavirus outbreak of global health concern

5. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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