Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast-Reference-Cited by-同舟云学术

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Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast

Published:2020-10-30 Issue:44 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kong Deze¹^ORCID,Li Sijin²^ORCID,Smolke Christina D.¹³^ORCID

Affiliation:

1. Department of Bioengineering, 443 Via Ortega, MC 4245, Stanford University, Stanford, CA 94305, USA.

2. Robert Frederick Smith School of Chemical and Biomolecular Engineering, 230A Olin Hall, Cornell University, Ithaca, NY 14853, USA.

3. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Abstract

A previously unknown chalcone synthase activity for HCAA synthesis is uncovered via characterization of a tomato gene cluster in yeast.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

1. Discovery and resupply of pharmacologically active plant-derived natural products: A review

2. Plants used in cosmetics

3. Synthetic biology strategies for microbial biosynthesis of plant natural products

4. Strategies for microbial synthesis of high-value phytochemicals

5. Plant metabolic clusters – from genetics to genomics

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1. Beyond co-expression: pathway discovery for plant pharmaceuticals;Current Opinion in Biotechnology;2024-08

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3. Hordatines, dimerised hydroxycinnamoylagmatine conjugates of barley (Hordeum vulgare L.): an appraisal of the biosynthesis, chemistry, identification and bioactivities;Phytochemistry Reviews;2024-04-09

4. Pathway Evolution Through a Bottlenecking‐Debottlenecking Strategy and Machine Learning‐Aided Flux Balancing;Advanced Science;2024-02-06

5. Synergetic Engineering of Multiple Pathways for De Novo (2S)-Naringenin Biosynthesis in Saccharomyces cerevisiae;ACS Sustainable Chemistry & Engineering;2023-12-20

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