The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands

Author:

Stielow Bastian1ORCID,Zhou Yuqiao2ORCID,Cao Yinghua2ORCID,Simon Clara1ORCID,Pogoda Hans-Martin34ORCID,Jiang Junyi2,Ren Yanpeng2,Phanor Sabrina Keita5ORCID,Rohner Iris1,Nist Andrea6,Stiewe Thorsten6ORCID,Hammerschmidt Matthias34ORCID,Shi Yang78ORCID,Bulyk Martha L.59,Wang Zhanxin2ORCID,Liefke Robert110ORCID

Affiliation:

1. Institute of Molecular Biology and Tumor Research (IMT), Philipps University of Marburg, 35043 Marburg, Germany.

2. Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, China.

3. Institute of Zoology, University of Cologne, Cologne, Germany.

4. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

5. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

6. Genomics Core Facility, Institute of Molecular Oncology, Member of the German Center for Lung Research (DZL), Philipps University of Marburg, 35043 Marburg, Germany.

7. Division of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children’s Hospital, Boston, Harvard Medical School, Boston, MA 02115, USA.

8. Ludwig Institute for Cancer Research, Oxford University, Oxford, UK.

9. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

10. Department of Hematology, Oncology and Immunology, University Hospital Giessen and Marburg, 35043 Marburg, Germany.

Abstract

SAMD1 is a newly identified repressive CpG island regulator.

Funder

National Institutes of Health

Deutsche Forschungsgemeinschaft

National Natural Science Foundation of China

Fritz Thyssen Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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