Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin-Reference-Cited by-同舟云学术

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

Published:2021-05-28 Issue:22 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sponga Antonio¹^ORCID,Arolas Joan L.¹^ORCID,Schwarz Thomas C.¹^ORCID,Jeffries Cy M.²^ORCID,Rodriguez Chamorro Ariadna¹^ORCID,Kostan Julius¹^ORCID,Ghisleni Andrea³^ORCID,Drepper Friedel⁴⁵^ORCID,Polyansky Anton¹⁶,De Almeida Ribeiro Euripedes¹,Pedron Miriam¹^ORCID,Zawadzka-Kazimierczuk Anna⁷^ORCID,Mlynek Georg¹^ORCID,Peterbauer Thomas⁸,Doto Pierantonio¹,Schreiner Claudia¹^ORCID,Hollerl Eneda¹,Mateos Borja¹^ORCID,Geist Leonhard¹^ORCID,Faulkner Georgine⁹^ORCID,Kozminski Wiktor⁷^ORCID,Svergun Dmitri I.³^ORCID,Warscheid Bettina⁴⁵^ORCID,Zagrovic Bojan¹,Gautel Mathias³^ORCID,Konrat Robert¹,Djinović-Carugo Kristina¹¹⁰^ORCID

Affiliation:

1. Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, A-1030 Vienna, Austria.

2. European Molecular Biology Laboratory (EMBL), Hamburg Unit, Hamburg, Germany.

3. King’s College London BHF Centre for Research Excellence, Randall Centre for Cell and Molecular Biophysics, London SE1 1UL, UK.

4. Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

5. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

6. National Research University Higher School of Economics, Moscow 101000, Russia.

7. Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.

8. Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Dr. BohrGasse 9, A-1030 Vienna, Austria.

9. Department of Biology, University of Padova, 35100 Padova, Italy.

10. Department of Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.

Abstract

Sarcomeric proteins FATZ-1 and α-actinin-2 associate in a tight fuzzy complex, which forms phase-separated condensates.

Funder

Austrian Federal Ministry of Economy, Family and Youth

Deutsche Forschungsgemeinschaft

Vienna Science and Technology Fund

Austrian Science Fund

Christian Doppler Forschungsgesellschaft

COST Action

European Union’s Horizon 2020 research and innovation programme ‘iNEXT Discovery’

University of Vienna

Wellcome Trust Collaborative Award

Austrian-Slovak Interreg

Marie Curie Initial Training Network MUZIC

Polish National Science Centre

Germany’s Excellence Strategy CIBSS – EXC-2189

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference152 articles.

1. The sarcomeric Z-disc: a nodal point in signalling and disease

2. Targeting the sarcomere to correct muscle function

3. The sarcomeric cytoskeleton: from molecules to motion

4. The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling

5. Myofibrillogenesis visualized in living embryonic cardiomyocytes

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