MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway-Reference-Cited by-同舟云学术

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway

Published:2021-12-17 Issue:51 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Luzwick Jessica W.¹^ORCID,Dombi Eszter¹,Boisvert Rebecca A.¹,Roy Sunetra¹,Park Soyoung¹^ORCID,Kunnimalaiyaan Selvi¹^ORCID,Goffart Steffi²^ORCID,Schindler Detlev³^ORCID,Schlacher Katharina¹^ORCID

Affiliation:

1. Department of Cancer Biology, UT MD Anderson Cancer Center, Houston, TX, USA.

2. Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland.

3. Institut für Humangenetik, University of Würzburg, Würzburg, Germany.

Abstract

MRE11 activates mitochondrial DNA–dependent cGAS immune signaling in cells with BRCA/FANC gene defects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference88 articles.

1. Evolution of Mitochondria as Signaling Organelles

2. Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

3. Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

4. DAMP-sensing receptors in sterile inflammation and inflammatory diseases

5. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

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