Platelets amplify endotheliopathy in COVID-19

Author:

Barrett Tessa J.1ORCID,Cornwell MacIntosh12ORCID,Myndzar Khrystyna1,Rolling Christina C.1,Xia Yuhe1ORCID,Drenkova Kamelia1,Biebuyck Antoine1,Fields Alexander T.3,Tawil Michael1ORCID,Luttrell-Williams Elliot1ORCID,Yuriditsky Eugene1,Smith Grace4ORCID,Cotzia Paolo56,Neal Matthew D.7ORCID,Kornblith Lucy Z.3ORCID,Pittaluga Stefania3ORCID,Rapkiewicz Amy V.8ORCID,Burgess Hannah M.9ORCID,Mohr Ian9,Stapleford Kenneth A.9,Voora Deepak10,Ruggles Kelly2ORCID,Hochman Judith1ORCID,Berger Jeffrey S.111ORCID

Affiliation:

1. Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.

2. Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.

3. Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

4. Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

5. Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.

6. Center for Biospecimen Research, New York University Grossman School of Medicine, New York, NY, USA.

7. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

8. Department of Pathology, NYU Langone Long Island Hospital, New York University Langone Health, Mineola, NY, USA.

9. Department of Microbiology, New York University Langone Health, New York, NY, USA.

10. Department of Medicine, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC, USA.

11. Department of Surgery, New York University Langone Health, New York, NY, USA.

Abstract

Platelet-derived MRP8/14 amplifies endotheliopathy in COVID-19.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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