Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation-Reference-Cited by-同舟云学术

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lopez Juan Pablo¹²^ORCID,Brivio Elena¹²³^ORCID,Santambrogio Alice⁴⁵,De Donno Carlo¹²⁶,Kos Aron¹²^ORCID,Peters Miriam⁷,Rost Nicolas³⁸^ORCID,Czamara Darina⁸,Brückl Tanja M.⁸,Roeh Simone⁸^ORCID,Pöhlmann Max L.⁹^ORCID,Engelhardt Clara⁹,Ressle Andrea¹^ORCID,Stoffel Rainer¹,Tontsch Alina⁸^ORCID,Villamizar Javier M.⁷^ORCID,Reincke Martin⁷,Riester Anna⁷^ORCID,Sbiera Silviu¹⁰^ORCID,Fassnacht Martin¹⁰^ORCID,Mayberg Helen S.¹¹^ORCID,Craighead W. Edward¹²,Dunlop Boadie W.¹²^ORCID,Nemeroff Charles B.¹³^ORCID,Schmidt Mathias V.⁹^ORCID,Binder Elisabeth B.⁸^ORCID,Theis Fabian J.⁶¹⁴^ORCID,Beuschlein Felix⁷¹⁵^ORCID,Andoniadou Cynthia L.⁴⁵^ORCID,Chen Alon¹²¹⁶^ORCID

Affiliation:

1. Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Bavaria 80804, Germany.

2. The Max Planck Society–Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics, Rehovot 76100, Israel and Munich, Bavaria 80804, Germany.

3. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Bavaria 80804, Germany.

4. Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London SE11UL, UK.

5. Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony 01307, Germany.

6. Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria 85764, Germany.

7. Department for Endocrinology, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University, Munich, Bavaria 80336, Germany.

8. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Bavaria 80804, Germany.

9. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Bavaria 80804, Germany.

10. Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Bavaria 97080, Germany.

11. Departments of Neurology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

12. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA.

13. Department of Psychiatry, University of Texas at Austin Dell Medical School, Austin, TX 78738, USA.

14. Department of Mathematics, Technische Universität München, Munich, Bavaria 85748, Germany.

15. Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich 8091, Switzerland.

16. Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Dissection of the HPA axis using single-cell RNA sequencing uncovers adrenal ABCB1 as an important player of stress adaptation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. The Neuroendocrinology of Stress: A Never Ending Story

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5. Rapid non-genomic effects of corticosteroids and their role in the central stress response

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