NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4-Reference-Cited by-同舟云学术

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

Published:2021-05-07 Issue:19 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jain Pallavi¹,Dvorkin-Gheva Anna¹²,Mollen Erik¹³,Malbeteau Lucie¹,Xie Michael¹⁴,Jessa Fatima¹,Dhavarasa Piriththiv¹,Chung Stephen¹,Brown Kevin R.⁵,Jang Gun Ho⁶,Vora Parth¹⁴,Notta Faiyaz¹⁶⁷,Moffat Jason⁵⁷,Hedley David¹⁸,Boutros Paul C.⁹¹⁰,Wouters Bradly G.¹⁹¹¹,Koritzinsky Marianne¹⁴⁹¹¹

Affiliation:

1. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

2. Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

3. University of Maastricht, Maastricht, Netherlands.

4. Institute of Medical Science, University of Toronto, Toronto, Canada.

5. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada.

6. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

7. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

8. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

9. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

10. Departments of Human Genetics and Urology, University of California, Los Angeles, Los Angeles, CA, USA.

11. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

Abstract

Reductive power in the cytosol of pancreatic cancer cells drives a dependency on the endoplasmic reticulum protein PRDX4.

Funder

NIH Office of the Director

Cancer Research Society

Princess Margaret Cancer Foundation

Terry Fox Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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