The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes-Reference-Cited by-同舟云学术

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The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

Published:2020-10-16 Issue:42 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bender Christine¹^ORCID,Rodriguez-Calvo Teresa¹²^ORCID,Amirian Natalie¹,Coppieters Ken T.³,von Herrath Matthias G.¹⁴^ORCID

Affiliation:

1. Center for Type 1 Diabetes Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

2. The Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Diabetes Research, Munich-Neuherberg, Germany.

3. Global Research Project Management, Novo Nordisk, Måløv, Denmark.

4. The Novo Nordisk Research Center Seattle Inc., Seattle, WA, USA.

Abstract

Preproinsulin-specific CD8 + T cells residing in the exocrine pancreas become attracted to islets in type 1 diabetes.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Type 1 diabetes

2. Type 1 diabetes mellitus

3. Autoreactive T cells in type 1 diabetes

4. Insulitis in human type 1 diabetes: a comparison between patients and animal models

5. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

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