The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

Author:

Bender Christine1ORCID,Rodriguez-Calvo Teresa12ORCID,Amirian Natalie1,Coppieters Ken T.3,von Herrath Matthias G.14ORCID

Affiliation:

1. Center for Type 1 Diabetes Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

2. The Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Diabetes Research, Munich-Neuherberg, Germany.

3. Global Research Project Management, Novo Nordisk, Måløv, Denmark.

4. The Novo Nordisk Research Center Seattle Inc., Seattle, WA, USA.

Abstract

Preproinsulin-specific CD8 + T cells residing in the exocrine pancreas become attracted to islets in type 1 diabetes.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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