Three-dimensional microscale hanging drop arrays with geometric control for drug screening and live tissue imaging

Author:

Ganguli A.12ORCID,Mostafa A.12ORCID,Saavedra C.2,Kim Y.23,Le P.12ORCID,Faramarzi V.2ORCID,Feathers R. W.45,Berger J.12,Ramos-Cruz K. P.12ORCID,Adeniba O.2,Diaz G. J. Pagan12,Drnevich J.6ORCID,Wright C. L.7ORCID,Hernandez A. G.7ORCID,Lin W.45,Smith A. M.12389ORCID,Kosari F.410,Vasmatzis G.410,Anastasiadis P. Z.45ORCID,Bashir R.1248ORCID

Affiliation:

1. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2. Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

4. Mayo-Illinois Alliance for Technology-Based Healthcare, Urbana, IL, USA.

5. Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.

6. High-Performance Biological Computing, Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

7. DNA Services Lab, Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

8. Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, Urbana, IL 61820, USA.

9. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

10. Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

Tiny silicon microchip–based high-throughput hanging drop arrays allow drug screening and geometric control.

Funder

NSF Office of the Director

NIBIB

NIGMS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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