Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique

Author:

Ding Xianting1ORCID,Njus Zach2ORCID,Kong Taejoon2ORCID,Su Wenqiong1ORCID,Ho Chih-Ming3,Pandey Santosh2ORCID

Affiliation:

1. State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

2. Department of Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA.

3. Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

An engineering approach yields a highly potent combination of four antinematode drugs at lower dosages than individual drugs.

Funder

Defense Threat Reduction Agency

US National Science Foundation

China Science and Technology Innovation Zone

State Key Laboratory of Robotics Open Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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