The prefusion structure of herpes simplex virus glycoprotein B-Reference-Cited by-同舟云学术

The prefusion structure of herpes simplex virus glycoprotein B

Published:2020-09-25 Issue:39 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vollmer B.¹²^ORCID,Pražák V.¹^ORCID,Vasishtan D.¹,Jefferys E. E.³^ORCID,Hernandez-Duran A.⁴,Vallbracht M.⁵^ORCID,Klupp B. G.⁵,Mettenleiter T. C.⁵,Backovic M.⁶^ORCID,Rey F. A.⁶^ORCID,Topf M.⁴^ORCID,Grünewald K.¹²⁷^ORCID

Affiliation:

1. Oxford Particle Imaging Centre, Department of Structural Biology, Wellcome Centre Human Genetics, University of Oxford, Oxford, UK.

2. Centre for Structural Systems Biology, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Hamburg, Germany.

3. Department of Biochemistry, University of Oxford, Oxford, UK.

4. Institute of Structural and Molecular Biology, Birkbeck, London, UK.

5. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Insel Riems, Germany.

6. Institut Pasteur, Structural Virology Unit, Department of Virology, Paris, France.

7. Department of Chemistry, MIN Faculty, Universität Hamburg, Hamburg, Germany.

Abstract

Elusive, pharmacologically relevant conformation of the herpesvirus fusion protein is revealed by a multi-methodological approach.

Funder

Wellcome

H2020 Marie Skłodowska-Curie Actions

Medical Research Council

Institut Pasteur

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference66 articles.

1. Viral membrane fusion

2. Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

3. Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

4. A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

5. M. Backovic T. S. Jardetzky in Cell Fusion in Health and Disease II: Cell Fusion in Disease (2011) vol. 714 pp. 91–101.

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