The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1-Reference-Cited by-同舟云学术

The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1

Published:2021-03-05 Issue:10 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rao Bing¹^ORCID,Li Shaobai²,Yao Deqiang²,Wang Qian²,Xia Ying²,Jia Yi²,Shen Yafeng²,Cao Yu²³^ORCID

Affiliation:

1. CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China.

2. Shanghai Institute of Precision of Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai 200125, China.

3. Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Abstract

The structure of human Derlin-1 reveals the mechanism of misfolded protein transport across the ER membrane.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

2. In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases