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A transgenic mouse for imaging activity-dependent dynamics of endogenous Arc mRNA in live neurons

  • Published:2018-06 Issue:6 Volume:4 Page:
  • ISSN:2375-2548
  • Container-title:Science Advances
  • language:en
  • Short-container-title:Sci. Adv.

Author:

Das Sulagna1ORCID,Moon Hyungseok C.2ORCID,Singer Robert H.13ORCID,Park Hye Yoon24ORCID

Affiliation:

1. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

2. Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea.

3. Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.

4. The Institute of Applied Physics, Seoul National University, Seoul 08826, Korea.

Abstract

A transgenic mouse reveals real-time dynamics of transcription and transport of endogenous Arc mRNA in live neurons.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Single-molecule insights into mRNA dynamics in neurons;Buxbaum A. R.;Trends Cell Biol.,2015

2. Remote control of gene function by local translation;Jung H.;Cell,2014

3. Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace;Minatohara K.;Front. Mol. Neurosci.,2015

4. mRNA transport & local translation in neurons

5. Localization and local translation of Arc/Arg3.1 mRNA at synapses: Some observations and paradoxes;Steward O.;Front. Mol. Neurosci.,2015
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