Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

Author:

Zou Ke123ORCID,Rouskin Silvia4ORCID,Dervishi Kevin5,McCormick Mark A.67,Sasikumar Arjun8,Deng Changhui1,Chen Zhibing9ORCID,Kaeberlein Matt10ORCID,Brem Rachel B.8ORCID,Polymenis Michael11ORCID,Kennedy Brian K.8121314ORCID,Weissman Jonathan S.4ORCID,Zheng Jiashun1ORCID,Ouyang Qi23ORCID,Li Hao1ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

2. The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China.

3. Peking-Tsinghua Center for Life Sciences at Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

4. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, San Francisco, CA 94158, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

7. Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, Albuquerque, NM 87131, USA.

8. Buck Institute for Research on Aging, Novato, CA 94945, USA.

9. Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA 94158, USA.

10. Department of Pathology, University of Washington, Seattle, WA 98195, USA.

11. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

12. Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

13. Centre for Healthy Longevity, National University Health System, Singapore.

14. Singapore Institute for Clinical Sciences, A*STAR, Singapore.

Abstract

Yeast cells lower their intracellular methionine level in response to glucose restriction to regulate metabolism and life span.

Funder

Howard Hughes Medical Institute

NIH Office of the Director

American Federation for Aging Research Junior Faculty Grant

National Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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