NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Srivastava Shashank¹^ORCID,Sahu Umakant¹,Zhou Yalu¹,Hogan Ann K.¹^ORCID,Sathyan Kizhakke Mattada²^ORCID,Bodner Justin¹^ORCID,Huang Jiehuan¹^ORCID,Wong Kelvin A.¹^ORCID,Khalatyan Natalia³^ORCID,Savas Jeffrey N.³^ORCID,Ntziachristos Panagiotis¹⁴⁵,Ben-Sahra Issam¹⁴⁵,Foltz Daniel R.¹⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

2. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.

3. Department of Neurology Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

4. Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

5. Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

UBR7 supports nucleotide biosynthesis and NOTCH1-driven T cell acute lymphoblastic leukemia through regulation of PRPS enzymes.

Funder

Robert H. Lurie Comprehensive Cancer Center, Northwestern University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. Acute lymphoblastic leukemia: a comprehensive review and 2017 update

2. Acute Lymphoblastic Leukemia

3. Notch signaling at a glance;Hori K.;J. Cell Sci.,2013

4. Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

5. The role of NOTCH1 signaling in T-ALL

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