Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

Author:

He Linling1ORCID,Tzarum Netanel1ORCID,Lin Xiaohe1,Shapero Benjamin1ORCID,Sou Cindy1,Mann Colin J.1ORCID,Stano Armando1,Zhang Lei1,Nagy Kenna2ORCID,Giang Erick2,Law Mansun2ORCID,Wilson Ian A.13ORCID,Zhu Jiang12ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

An HCV vaccine strategy displays optimized E2 cores on nanoparticles for eliciting a cross-neutralizing B cell response.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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