MAGE cancer-testis antigens protect the mammalian germline under environmental stress

Author:

Fon Tacer Klementina1ORCID,Montoya Marhiah C.23ORCID,Oatley Melissa J.4,Lord Tessa4ORCID,Oatley Jon M.4,Klein Jonathon1,Ravichandran Ramya1,Tillman Heather5,Kim MinSoo6,Connelly Jon P.1,Pruett-Miller Shondra M.1ORCID,Bookout Angie L.7,Binshtock Emily1ORCID,Kamiński Marcin M.8ORCID,Potts Patrick Ryan1ORCID

Affiliation:

1. Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA.

2. Clinical & Translational Science Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

3. Departments of Pediatrics, Microbiology and Immunology, Carver College of Medicine, University of Iowa, IA, USA.

4. Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.

5. Veterinary Pathology Core, St. Jude Children’s Research Hospital, Memphis, TN, USA.

6. Departments of Internal Medicine and Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

7. Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

8. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA.

Abstract

Mammals evolved testis-specific Mage-a genes to protect the male germline under starvation stress and are co-opted in cancer.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference48 articles.

1. D. Lack in Evolution as a Process J. Huxley A. C. Hardy E. B. Ford Eds. (George Allen and Unwin 1954) pp. 143–156.

2. The nature and dynamics of spermatogonial stem cells;de Rooij D. G.;Development,2017

3. Spermatogenesis: The commitment to meiosis;Griswold M. D.;Physiol. Rev.,2016

4. Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals

5. Regulation of spermatogenesis: An evolutionary biologist's perspective;Schlatt S.;Semin. Cell Dev. Biol.,2014

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