No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication-Reference-Cited by-同舟云学术

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication

Published:2019-09-06 Issue:9 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bozzi G.¹²^ORCID,Simonetti F. R.¹²^ORCID,Watters S. A.¹³^ORCID,Anderson E. M.¹^ORCID,Gouzoulis M.¹,Kearney M. F.¹^ORCID,Rote P.¹^ORCID,Lange C.¹,Shao W.⁴,Gorelick R.⁵^ORCID,Fullmer B.⁵^ORCID,Kumar S.⁶^ORCID,Wank S.⁶,Hewitt S.⁷^ORCID,Kleiner D. E.⁷⁸^ORCID,Hattori J.¹^ORCID,Bale M. J.¹,Hill S.¹,Bell J.¹,Rehm C.⁹^ORCID,Grossman Z.¹,Yarchoan R.¹⁰^ORCID,Uldrick T.¹⁰^ORCID,Maldarelli F.¹^ORCID

Affiliation:

1. HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD, USA.

2. Department of Biomedical and Clinical Sciences, L. Sacco Hospital, University of Milan, Milan, Italy.

3. Department of Infection and Immunity, University College London, London, UK.

4. Advanced Biomedical Computing Center, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

5. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

6. Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD, USA.

7. Laboratory of Pathology, NCI, NIH, Bethesda, MD, USA.

8. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

9. Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA.

10. HIV and AIDS Malignancy Branch, NCI, NIH, Bethesda, MD, USA.

Abstract

Long-term persistence, not ongoing virus replication, is primarily responsible for maintaining HIV during antiretroviral therapy.

Funder

National Institutes of Health

National Cancer Institute

National Institutes of Health,

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

2. The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies

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