TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy-Reference-Cited by-同舟云学术

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Published:2021-11-05 Issue:45 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Alquezar Carolina¹^ORCID,Schoch Kathleen M.²,Geier Ethan G.³,Ramos Eliana Marisa⁴,Scrivo Aurora⁵,Li Kathy H.⁶,Argouarch Andrea R.¹^ORCID,Mlynarski Elisabeth E.⁷^ORCID,Dombroski Beth⁷^ORCID,DeTure Michael⁸^ORCID,Dickson Dennis W.⁸^ORCID,Yokoyama Jennifer S.³,Cuervo Ana M.⁵^ORCID,Burlingame Alma L.⁶^ORCID,Schellenberg Gerard D.⁷^ORCID,Miller Timothy M.²^ORCID,Miller Bruce L.¹^ORCID,Kao Aimee W.¹^ORCID

Affiliation:

1. UCSF Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.

2. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.

4. Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

5. Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.

6. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA.

7. Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

8. Department of Neuroscience, The Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Abstract

TSC1/hamartin haploinsufficiency increases risk for tauopathy by promoting tau acetylation and accumulation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. Anatamopathological spectrum of tauopathies

2. The role of protein clearance mechanisms in organismal ageing and age-related diseases

3. Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

4. The acetylation of tau inhibits its function and promotes pathological tau aggregation

5. Tau post-translational modifications: Dynamic transformers of tau function, degradation, and aggregation;Alquezar C.;Front. Neurol.,2020

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration;Autophagy;2024-09-10

2. Interaction between resveratrol and SIRT1: role in neurodegenerative diseases;Naunyn-Schmiedeberg's Archives of Pharmacology;2024-08-06

3. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies;Translational Neurodegeneration;2024-08-06

4. Microbial species exist and are maintained by ecological cohesiveness coupled to high homologous recombination;2024-05-25

5. Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies;Journal of Neurology;2024-03-30