Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease-Reference-Cited by-同舟云学术

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mattsson-Carlgren Niklas¹²³^ORCID,Andersson Emelie¹,Janelidze Shorena¹,Ossenkoppele Rik¹⁴,Insel Philip¹,Strandberg Olof¹,Zetterberg Henrik⁵⁶⁷⁸,Rosen Howard J.⁹^ORCID,Rabinovici Gil⁹,Chai Xiyun¹⁰,Blennow Kaj⁵⁶^ORCID,Dage Jeffrey L.¹⁰^ORCID,Stomrud Erik¹^ORCID,Smith Ruben¹²^ORCID,Palmqvist Sebastian¹²,Hansson Oskar¹¹¹^ORCID

Affiliation:

1. Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.

2. Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.

3. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

4. VU University Medical Center, Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, Amsterdam, Netherlands.

5. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

6. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

7. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.

8. UK Dementia Research Institute, London, UK.

9. Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

10. Eli Lilly and Company, Indianapolis, IN, USA.

11. Memory Clinic, Skåne University Hospital, Malmö, Sweden.

Abstract

Aβ pathology may induce changes in soluble tau release and phosphorylation, which is later followed by tau aggregation.

Funder

Parkinson Research Foundation

H2020 European Research Council

Swedish Research Council Formas