The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin-Reference-Cited by-同舟云学术

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Published:2020-04-03 Issue:14 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sarkar Saswata S.¹²^ORCID,Trivedi Darshan V.¹²^ORCID,Morck Makenna M.¹²^ORCID,Adhikari Arjun S.¹²,Pasha Shaik N.³,Ruppel Kathleen M.¹²⁴^ORCID,Spudich James A.¹²^ORCID

Affiliation:

1. Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. National Centre for Biological Sciences (TIFR), GKVK Campus, Bellary Road, Bangalore, India.

4. Department of Pediatrics (Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Hypertrophic cardiomyopathy–causing mutations disrupt a key regulatory off state of myosin in thick filaments.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

2. Cellular mechanisms of cardiomyopathy

3. Genetics of hypertrophic cardiomyopathy

4. Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

5. The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

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