Structural basis of sterol recognition by human hedgehog receptor PTCH1-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Structural basis of sterol recognition by human hedgehog receptor PTCH1

Published:2019-09-06 Issue:9 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Qi Chao¹^ORCID,Di Minin Giulio²^ORCID,Vercellino Irene³^ORCID,Wutz Anton²^ORCID,Korkhov Volodymyr M.¹³^ORCID

Affiliation:

1. Institute of Biochemistry, ETH Zürich, Zürich, Switzerland.

2. Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.

3. Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.

Abstract

Cryo-EM structure of PTCH1-ShhN C24II complex reveals multiple sterol binding sites and a possible sterol translocation pathway.

Funder

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. The mechanisms of Hedgehog signalling and its roles in development and disease

2. Mechanisms and functions of Hedgehog signalling across the metazoa

3. Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly;Ming J. E.;Hum. Genet.,2002

4. A recurrent mosaic mutation in SMO, encoding the hedgehog signal transducer smoothened, is the major cause of Curry-Jones syndrome;Twigg S. R. F.;Am. J. Hum. Genet.,2016

5. Cancer surveillance in Gorlin syndrome and Rhabdoid tumor predisposition syndrome;Foulkes W. D.;Clin. Cancer Res.,2017

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. High-resolution cryo-EM structures of a protein pore reveal diverse roles of membrane lipids;2024-06-26

2. A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor;Journal of Developmental Biology;2024-04-09

3. LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins;Nature Communications;2023-11-27

4. The energetics and ion coupling of cholesterol transport through Patched1;Science Advances;2023-08-25

5. Hedgehog-Related Mutation Causes Bone Malformations with or without Hereditary Gene Mutations;International Journal of Molecular Sciences;2023-08-17

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3