Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway-Reference-Cited by-同舟云学术

Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway

Published:2020-06-05 Issue:23 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kemble Harry¹²^ORCID,Eisenhauer Catherine¹^ORCID,Couce Alejandro¹³,Chapron Audrey¹^ORCID,Magnan Mélanie¹^ORCID,Gautier Gregory⁴⁵,Le Nagard Hervé¹^ORCID,Nghe Philippe²,Tenaillon Olivier¹^ORCID

Affiliation:

1. IAME, INSERM, Université de Paris, Université Paris Nord, 75018 Paris, France.

2. Laboratory of Biochemistry (LBC), Chimie Biologie et Innovation, ESPCI Paris, PSL University, CNRS, 75005 Paris, France.

3. Department of Life Sciences, Imperial College, London SW7 2AZ, UK.

4. Centre de Recherche sur l'Inflammation, INSERM, UMRS 1149, 75018 Paris, France.

5. Laboratoire d’Excellence INFLAMEX, Université de Paris, Sorbonne Paris Cité, 75018 Paris, France.

Abstract

Complex fitness interactions between alleles and expression-modulating environment are explained by a simple metabolic model.

Funder

FP7 Ideas: European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Monogenic traits are not simple: lessons from phenylketonuria

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