Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins

Author:

Khalil Andrew S.12ORCID,Yu Xiaohua123,Umhoefer Jennifer M.4ORCID,Chamberlain Connie S.2ORCID,Wildenauer Linzie A.2ORCID,Diarra Gaoussou M.5,Hacker Timothy A.5,Murphy William L.1267ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53705, USA.

2. Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA.

3. Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, PR China.

4. Department of Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.

5. Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA.

6. Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53705, USA.

7. Forward BIO Institute, University of Wisconsin-Madison, Madison, WI 53705, USA.

Abstract

Nanostructured mineral coatings delivering chemically modified or unmodified therapeutic mRNA improve diabetic wound healing.

Funder

National Science Foundation

National Institutes of Health

U.S. Environmental Protection Agency

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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