Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

Author:

Kerselidou Despoina12ORCID,Dohai Bushra Saeed3ORCID,Nelson David R.4ORCID,Daakour Sarah4,De Cock Nicolas5ORCID,Hassoun Zahra Al Oula2ORCID,Kim Dae-Kyum678,Olivet Julien1ORCID,El Assal Diana C.3ORCID,Jaiswal Ashish4ORCID,Alzahmi Amnah4,Saha Deeya12ORCID,Pain Charlotte9ORCID,Matthijssens Filip1011ORCID,Lemaitre Pierre12ORCID,Herfs Michael13,Chapuis Julien14ORCID,Ghesquiere Bart15ORCID,Vertommen Didier16ORCID,Kriechbaumer Verena9ORCID,Knoops Kèvin17ORCID,Lopez-Iglesias Carmen17,van Zandvoort Marc18,Lambert Jean-Charles14ORCID,Hanson Julien19ORCID,Desmet Christophe12ORCID,Thiry Marc20ORCID,Lauersen Kyle J.21ORCID,Vidal Marc2223ORCID,Van Vlierberghe Pieter1011ORCID,Dequiedt Franck2ORCID,Salehi-Ashtiani Kourosh34ORCID,Twizere Jean-Claude1522ORCID

Affiliation:

1. Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.

2. Laboratory of Gene expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium.

3. Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE.

4. Center for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, Abu Dhabi, UAE.

5. TERRA Teaching and Research Centre, University of Liege, Liege, Belgium.

6. The Donnelly Centre, University of Toronto, Toronto, ON, Canada.

7. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

8. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

9. Plant Cell Biology, Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.

10. Department of Biomolecular Medicine and Center for Medical Genetics, Ghent University, Ghent, Belgium.

11. Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

12. GIGA-I3 Unit, GIGA Institute, University of Liege, Liege, Belgium.

13. GIGA-Cancer Unit, GIGA Institute, University of Liege, Liege, Belgium.

14. Laboratory of Excellence Distalz, INSERM Unit 1167, Pasteur Institute of Lille, Lille, France.

15. Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.

16. de Duve Institute, Catholic University of Louvain, Brussels, Belgium.

17. Microscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.

18. Department of Cell Biology, School for Cardiovascular Diseases (CARIM), School for Nutrition and Translational Research in Metabolism (NUTRIM), School for Mental health and Neuroscience (MHeNS), and School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, Netherlands.

19. GIGA-Molecular Pharmacology, University of Liege, Liege, Belgium.

20. Laboratory of cell and tissue Biology, GIGA-Neurosciences, University of Liege, Liege, Belgium.

21. Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.

22. Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.

23. Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Abstract

Integration of multiomics and imaging identifies a glycosyltransferase enzyme regulating endoplasmic reticulum sizes.

Funder

New York University Abu Dhabi

National Research Foundation of Korea

Fonds Léon Fredericq

Fonds National de la Recherche Scientifique Belge

Banting Postdoctoral Fellowship of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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