Awake functional MRI detects neural circuit dysfunction in a mouse model of autism-Reference-Cited by-同舟云学术

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Published:2020-02-07 Issue:6 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Tsurugizawa Tomokazu¹^ORCID,Tamada Kota²,Ono Nobukazu³^ORCID,Karakawa Sachise³,Kodama Yuko³,Debacker Clement¹^ORCID,Hata Junichi²⁴,Okano Hideyuki²⁴^ORCID,Kitamura Akihiko³,Zalesky Andrew⁵,Takumi Toru²⁶^ORCID

Affiliation:

1. NeuroSpin, Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA Saclay, Gif-sur-Yvette 91191, France.

2. RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

3. Institute for Innovation, Ajinomoto Co. Inc., Kawasaki 210-8681, Japan.

4. Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8585, Japan.

5. Melbourne Neuropsychiatry Centre and Department of Biomedical Engineering, University of Melbourne, Victoria 3010, Australia.

6. Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan.

Abstract

Awake fMRI detects the hypoconnectivity partially rescued by d -cycloserine treatment in 15q dup mice.

Funder

the Takeda Science Foundation

JST CREST

KAKENHI Grant-in-Aid for Scientific Research

KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas, and Challenging Exploratory Research

Ajinomoto Co., Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Behavioral neuroscience of autism;Takumi T.;Neurosci. Biobehav. Rev.,2019

2. CNV biology in neurodevelopmental disorders

3. Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism

4. Decreased Exploratory Activity in a Mouse Model of 15q Duplication Syndrome; Implications for Disturbance of Serotonin Signaling

5. Enhanced synapse remodelling as a common phenotype in mouse models of autism

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