The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Author:

Berthelet Jean12ORCID,Wimmer Verena C.34ORCID,Whitfield Holly J.45ORCID,Serrano Antonin146ORCID,Boudier Thomas34ORCID,Mangiola Stefano45ORCID,Merdas Michal12ORCID,El-Saafin Farrah12ORCID,Baloyan David12,Wilcox Jordan12ORCID,Wilcox Steven34,Parslow Adam C.12ORCID,Papenfuss Anthony T.4578ORCID,Yeo Belinda129ORCID,Ernst Matthias12,Pal Bhupinder12,Anderson Robin L.1278,Davis Melissa J.4510ORCID,Rogers Kelly L.34ORCID,Hollande Frédéric1011ORCID,Merino Delphine1246ORCID

Affiliation:

1. Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.

2. School of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia.

3. Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

4. Department of Medical Biology, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Parkville, VIC 3010, Australia.

5. Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

6. Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

7. Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

8. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia.

9. Austin Health, Heidelberg, VIC 3084, Australia.

10. Department of Clinical Pathology, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Melbourne, VIC 3000, Australia.

11. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC 3000, Australia.

Abstract

Optical barcoding reveals enhanced TNFα activation and polyclonality in lung, but not liver, metastases from breast cancer.

Funder

Susan G. Komen

National Breast Cancer Foundation

Cancer Australia

Susan 1134 Komen and Cancer Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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