cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing T regs-Reference-Cited by-同舟云学术

cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing T regs

Published:2019-05-03 Issue:5 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kawalkowska Joanna Z.¹^ORCID,Ogbechi Joy¹^ORCID,Venables Patrick J.¹,Williams Richard O.¹^ORCID

Affiliation:

1. Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK.

Abstract

Scientists reveal a role for apoptotic proteins in rheumatoid arthritis and show that therapeutic inhibition induces remission.

Funder

European Union funded Seventh Framework Programme project “Profiling Responder in Antibody Therapies” (PRIAT).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

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2. Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy;Knights A. J.;Cancer Immunol. Immunother.,2013

3. Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors;Varfolomeev E.;Sci. Signal.,2012

4. IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

5. c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

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